The WblC/WhiB7 Transcription Factor Controls Intrinsic Resistance to Translation-Targeting Antibiotics by Altering Ribosome Composition
ABSTRACT Bacteria that encounter antibiotics can efficiently change their physiology to develop resistance.This intrinsic antibiotic resistance is mediated by multiple pathways, including a regulatory system(s) that activates specific genes.In some Streptomyces and Mycobacterium spp., the WblC/WhiB7 transcription factor is required for intrinsic re